A Randomized Comparison of Post-prandial Glucose Excursion Using Inhaled Insulin Versus Rapid-acting Analogue Insulin in Adults with Type 1 Diabetes Using Multiple Daily Injections of Insulin or Automated Insulin Delivery

• DOI: 10.2337/figshare.26117719.v1
• Publication Date: 2024-07-23T16:50:55Z
• Authors: Irl B. Hirsch; Roy W. Beck; Martin Chase Marak; Peter Calhoun; Adham Mottalib; Amna Salhin; Anastasios Manessis; Andrea D. Coviello; Anuj Bhargava; Ashley Thorsell; Astrid Atakov-Cas...; Bruce W Bode; Camilla Levister; Carol J. Levy; Cassandra Donahue; Christian Cordero; Christie Beatson; Christine R. Langel; Christopher Jacobson; Corey Kurek; David Pickering; Dana Cruse; Denisa Tamarez; Devin W. Steenkamp; Donna Desjardins; Grazia Aleppo; Grenye O’Malley; Halis K. Akturk; Jamie Diner; Jesica D. Baran; John B. Buse; Katrina Ruedy; Klara R. Klein; Kristin Castorino; Lin Fan Jordan; Mark Kipnes; Mei Mei Church; Osama Hamdy; Philip Raskin; Quang T. Nguyen; Ruth S. Weinstock; Scott Lee; Shafaq Rizvi; Suzan Bzdick; Tahereh Ghorbani ...; Tareq Salah; Thomas Blevins; Yogish C. Kudva; Zehra Haider
• Keywords: Insulin delivery

<p dir="ltr">Objective: To compare post-prandial glucose excursions following a bolus with inhaled technosphere insulin (TI) or subcutaneous rapid-acting analogue (RAA) insulin. </p><p dir="ltr">Research Design and Methods: A meal challenge was completed by 122 adults type 1 diabetes using multiple daily injections (MDI), non-automated pump, automated delivery (AID) who were randomized to their usual RAA (N=61) TI (N=61). dir="ltr">Results: The primary outcome, the treatment group difference in area under curve for >180mg/dL over 2 hours, less versus (adjusted difference, dir="ltr">-12mg/dL, 95% CI -22 -2, P=0.02). With TI, excursion smaller (P=0.01), peak lower time shorter (P=0.006). Blood <70mg/dL occurred one participant each group.</p><p dir="ltr">Conclusions: Post-meal than cohort that included both AID MDI users.</p>