Effect on the Skin Microbiota of Oral Minocycline for Rosacea

• DOI: 10.2340/actadv.v103.10331
• Publication Date: 2023-10-03T11:36:03Z
• Authors: Yiyi Zhang; Ying Zhou; Philippe Humbert; Dengfeng Yuan; Chao Yuan
• Keywords: Minocycline; Cheek

In the rosacea an unstable skin microbiota is significant for disease progression. However, data on influence of treatment with systemic antibiotics are limited. This single-arm trial recruited patients rosacea. Oral minocycline 50 mg was administered twice daily 6 weeks. The lesions cheek and nose were sampled 16S rRNA amplicon sequencing metagenomic at baseline, 3 weeks treatment. Physiological parameters detected using non-invasive instruments. After treatment, distribution Investigator Global Assessment scores changed significantly. For microbiota, a notable increase in α-diversity shift structure observed after Treatment accompanied by reduction relative abundance Cutibacterium Staphylococcus, indicating negative correlations increased bacterial metabolic pathways, such as butyrate synthesis L-tryptophan degradation. tryptophan metabolites would be conducive to inhibiting inflammation promoting barrier repair. addition, genes related tetracycline resistance multidrug notably antibiotic