Circadian variation in patients with acute heart failure with preserved ejection fraction

• DOI: 10.23736/s2724-5683.24.06665-1
• Publication Date: 2025-03-26T08:51:29Z
• Authors: Kenichi MATSUSHITA; Kazumasa HARADA; Takahiro JIMBA; Takashi KOHNO; Hiroki NAKANO; Akito SHINDO; Makoto TAKEI; Shun KOHSAKA; Hideaki YOSHINO; Takeshi YAMAMOTO; Ken NAGAO; Morimasa TAKAYAMA
• Keywords: Variation (astronomy)

The circadian system influences the pathophysiology of many cardiovascular diseases; however, variations in patients with heart failure preserved ejection fraction (HFpEF) are unknown. Thus, this study aimed to compare clinical characteristics and risk factors for in-hospital mortality between daytime- versus nighttime-onset HFpEF. This multicenter retrospective included 3875 consecutive acute Daytime nighttime periods were defined as 6:00-17:59 18:00-5:59, respectively. Potential prognostic selected using univariable analyses. Those P values <0.10 used multivariable logistic regression analyses forward selection (likelihood ratios) identify significant factors. incidence daytime-onset HFpEF was significantly lower but higher than that Independent age (odds ratio [OR], 1.057) systolic blood pressure (OR: 0.979). In contrast, 1.067), coexisting atrial fibrillation/flutter 2.023), 0.989), estimated glomerular filtration rate 0.971), treatment diuretics 0.282), beta-blockers 0.514) independent exhibits variations, onset-related differences identified. These findings may provide new insights future research guide individualized patient management strategies.