Scopolamine causes delirium-like brain network dysfunction and reversible cognitive impairment without neuronal loss

• DOI: 10.24272/j.issn.2095-8137.2022.473
• Publication Date: 2023-06-12T15:59:57Z
• Authors: Qing Wang; ; ; Xiang Zhang; Yu-Jie Guo; Ya-Yan Pang; Jun-Jie Li; Yan-Li Zhao; Jun-Fen Wei; Bai-Ting Zhu; Jing-Xiang Tang; Yang-Yang Jiang; Jie Meng; Ji-Rong Yue; Peng Lei
• Keywords: Memantine

Delirium is a severe acute neuropsychiatric syndrome that commonly occurs in the elderly and considered an independent risk factor for later dementia. However, given its inherent complexity, few animal models of delirium have been established mechanism underlying onset remains elusive. Here, we conducted comparison three mouse induced by clinically relevant factors, including anesthesia with surgery (AS), systemic inflammation, neurotransmission modulation. We found both bacterial lipopolysaccharide (LPS) cholinergic receptor antagonist scopolamine (Scop) induction reduced neuronal activities delirium-related brain network, latter presenting similar pattern reduction as patients. Consistently, Scop injection resulted reversible cognitive impairment hyperactive behavior. No loss neurons was treatment, but hippocampal synaptic functions were affected. These findings provide further clues regarding demonstrate successful application model mimicking delirium-like phenotypes mice.