Melatonin prevents nicotine-induced hepatotoxicity by modulating apoptosis and histopathological changes in rats

• DOI: 10.24425/pjvs.2024.152949
• Publication Date: 2024-12-20T20:15:51Z
• Authors: S.A. Şengül; I. İçen Taşkın; F. Aşır; A. Eraslan Şakar; G. Pektanç Şengül
• Keywords: 0402 animal and dairy science; 04 agricultural and veterinary sciences

Nicotine, the main toxic component of tobacco, directly or indirectly causes adverse effects on liver metabolism. Melatonin, secreted by pineal gland, has anti-apoptotic activity as well antioxidant activity. The aim this study was to reveal antiapoptotic melatonin in rats with experimentally induced chronic damage nicotine. In study, 32 male Wistar albino were divided into four groups: control, melatonin, nicotine and nicotine+melatonin. During experiment, (1 mg/kg) (10 administered daily intraperitoneally for 56 days. At end tissues taken histopathological, immunohistochemical molecular analysis. administration determined partially alleviate histopathological changes tissue nicotine, such hepatocyte degeneration, vascular dilatation congestion, leukocyte infiltration. It observed that there a significant decrease Bax expression levels increase Bcl-2 nicotine+melatonin group when compared injury group. On other hand, it reduced Bax/Bcl-2 ratio, which significantly higher groups, level close control Additionally, result evaluation, decreased increased hepatocytes at Our results revealed is hepatoprotective effective suppressing cell apoptosis increasing rate healing after both levels.