Protection by vaccination against bovine leukemia virus infection in sheep

• DOI: 10.2460/ajvr.1984.45.06.1212
• Publication Date: 2025-02-06T21:14:58Z
• Authors: M. Onuma; T. Hodatsu; S. Yamamoto; M. Higashihara; S. Masu; T. Mikami; H. Izawa
• Keywords: Bovine leukemia virus

SUMMARY Four preparations were tested as potential vaccines to protect sheep against bovine leukemia virus ( blv ) infection. Purified glycoprotein (gp) 51 and protein (p) 24 antigens from the glutaraldehyde-fixed fetal lamb kidney flk cells chronically infected with or fibroblasts transformed (SF-28 cells) used inoculate 12 sheep. Each vaccine was given 3 times 2 4 weeks apart Six vaccinated gp51 antigen fixed developed complement-fixing antibody gp51; titers ranged 1:8 1:128 at time of challenge exposure postinoculation week 9. Although 6 inoculated p24 SF-28 respective inoculum, none these had exposure. All control exposed -infected lymphocytes, subsequently for infection by syncytium assay. Sheep protected, but became infected. The cytotoxic activity lymphocytes protected nonprotected not different that normal Seemingly, purified capable preventing in Humoral immune responses appears have an important role protection infection, whereas does not.