Effects of continuous oral administration of phenylbutazone on biomarkers of cartilage and bone metabolism in horses

• DOI: 10.2460/ajvr.68.2.128
• Publication Date: 2007-02-03T06:41:18Z
• Authors: Marie-Ève Fradette; Christophe Céleste; Hèléne Richard; Guy Beauchamp; Sheila Laverty
• Keywords: Bone remodeling

Abstract Objective —To evaluate the effects of continuous oral administration phenylbutazone on serum and synovial fluid biomarkers skeletal matrix metabolism in horses. Animals —11 adult female horses without clinical or radiographic evidence joint disease. Procedures —Horses were randomly assigned to control treatment groups. Phenylbutazone was administered orally twice daily at a dose 4.4 mg/kg for 3 days group subsequently 2.2 7 days. Serum radiocarpal samples obtained baseline thereafter regular intervals 4 weeks. Biomarkers cartilage aggrecan synthesis (chondroitin sulfate 846) type II collagen (procollagen C-propeptide) degradation (collagen cleavage) assayed. bone (osteocalcin) resorption (C-terminal telopeptide I collagen) also measured. Results —No significant differences found between groups temporally chondroitin 846, procollagen C-propeptide, cleavage, C-terminal fluid. A increase osteocalcin concentration occurred during treated group. No effect detected concentration. Conclusions Clinical Relevance —Results suggested that recommended doses altered some healthy equine joints after short periods administration. Increased may indicate an undetermined anabolic periarticular transient induction osteogenesis articular chondrocytes mesenchymal subpopulation synoviocytes.