Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs

• DOI: 10.2460/ajvr.68.3.258
• Publication Date: 2007-03-02T02:24:15Z
• Authors: Stelio P. L. Luna; Ana C. Basílio; Paulo V. M. Steagall; Luciana P. Machado; Flávia Q. Moutinho; Regina K. Takahira; Cláudia V. S. Bra...
• Keywords: Carprofen; Meloxicam; Etodolac; Ketoprofen

Abstract Objective —To evaluate adverse effects of long-term oral administration carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs. Animals —36 adult Procedures —Values for CBC, urinalysis, serum biochemical urinalyses, occult blood feces were investigated before 7, 30, 60, 90 days after daily (n = 6 dogs/group) lactose (1 mg/kg, control treatment), etodolac (15 mg/kg), (0.1 carprofen (4 ketoprofen (2 mg/kg 4 days, followed by 1 thereafter) or 3 with 4-day intervals). Gastroscopy was performed the end treatment. Results —For γ-glutamyltransferase activity, values significantly increased at day 30 dogs treated lactose, within groups. Bleeding time compared baseline. At 7 bleeding longer meloxicam, flunixin, Clotting all groups except those etodolac. 90, clotting shorter flunixin-treated dogs, lactose-treated Gastric lesions detected carprofen. Conclusions Clinical Relevance —Carprofen induced lowest frequency gastrointestinal effects, meloxicam. Monitoring should be considered when nonsteroidal anti-inflammatory drugs are used to treat chronic pain.