Bioavailability of a novel midazolam gel after intranasal administration in dogs

• DOI: 10.2460/ajvr.73.4.539
• Publication Date: 2012-03-27T19:05:57Z
• Authors: Joseph S. Eagleson; Simon R. Platt; Deborah L. Elder ...; Marc Kent; Anne C. Freeman; Peter P. Nghiem; Bo Zheng; Catherine A. White
• Keywords: Midazolam; Rectal administration; Crossover study

Abstract Objective —To compare the pharmacokinetics of a novel bioadhesive gel formulation midazolam after intranasal (IN) administration with that solution IN, IV, and rectal to dogs. Animals —10 (5 males 5 females) healthy adult Beagles. Procedures —Dogs were assigned 4 treatment groups for crossover study design. Initially, mg/mL) was administered (0.2 mg/kg) IV group 1, rectally 2, IN 3; 0.4% hydroxypropyl methylcellulose (50 mg/kg, IN) 4. Each dog received all treatments; there 7-day washout period between subsequent treatments. Blood samples collected before administration. Plasma concentration determined by use high-performance liquid chromatography. Results —The peak plasma significantly higher than solution. Mean ± SD time 11.70 2.63 minutes (gel IN), 17.50 2.64 (solution 39 14.49 rectally). bioavailability 70.4% 52.0% 49.0% Bioavailability Conclusions Clinical Relevance —IN superior both respect bioavailability.