Inheritance of associated ocular and skeletal dysplasia in Labrador Retrievers

Male Eye Diseases 04 agricultural and veterinary sciences Syndrome 0403 veterinary science Radiography 03 medical and health sciences 0302 clinical medicine Dogs Retinal Diseases Animals Female Hip Dysplasia, Canine Dog Diseases Hip Dislocation, Congenital
DOI: 10.2460/javma.1988.193.10.1269 Publication Date: 2025-02-06T18:36:58Z
ABSTRACT
Summary A breeding colony was established to investigate the inheritance of associated ocular and skeletal dysplasia in Labrador Retrievers; 124 pups were produced. These pups were evaluated for the presence of ocular lesions, including cataracts, vitreous strands, persistent hyaloid remnants, retinal folds, retinal dysplasia, peripapillary hyperreflectivity, and rhegmatogenous retinal detachments, and skeletal abnormality, which was recognized by shorter than normal forelimbs and an abnormal morphologic appearance of the radius and ulna. Analysis of the distribution of lesions in pups indicated that the syndrome is caused by one abnormal gene, which has recessive effects on the skeleton and incompletely dominant effects on the eye. This would suggest that suspect carrier dogs could be identified by test matings with a known homozygote.
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