Inheritance of associated ocular and skeletal dysplasia in Labrador Retrievers
Male
Eye Diseases
04 agricultural and veterinary sciences
Syndrome
0403 veterinary science
Radiography
03 medical and health sciences
0302 clinical medicine
Dogs
Retinal Diseases
Animals
Female
Hip Dysplasia, Canine
Dog Diseases
Hip Dislocation, Congenital
DOI:
10.2460/javma.1988.193.10.1269
Publication Date:
2025-02-06T18:36:58Z
AUTHORS (4)
ABSTRACT
Summary
A breeding colony was established to investigate the inheritance of associated ocular and skeletal dysplasia in Labrador Retrievers; 124 pups were produced. These pups were evaluated for the presence of ocular lesions, including cataracts, vitreous strands, persistent hyaloid remnants, retinal folds, retinal dysplasia, peripapillary hyperreflectivity, and rhegmatogenous retinal detachments, and skeletal abnormality, which was recognized by shorter than normal forelimbs and an abnormal morphologic appearance of the radius and ulna.
Analysis of the distribution of lesions in pups indicated that the syndrome is caused by one abnormal gene, which has recessive effects on the skeleton and incompletely dominant effects on the eye. This would suggest that suspect carrier dogs could be identified by test matings with a known homozygote.
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