Serum C-reactive protein concentrations in dogs with multicentric lymphoma undergoing chemotherapy

• DOI: 10.2460/javma.230.4.522
• Publication Date: 2007-02-15T12:57:48Z
• Authors: Alexandre Merlo; Bárbara Cristina ...; Maria Luisa Franc...; Denise Maria Nune...; Sílvia Regina Ric...
• Keywords: Male; Lymphoma; Remission Induction; 04 agricultural and veterinary sciences; 3. Good health; Cohort Studies; 0403 veterinary science; C-Reactive Protein; Dogs; Treatment Outcome; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Animals; Female; Neoplasm Recurrence, Local

Abstract Objective —To determine whether serum C-reactive protein (CRP) concentration is high in dogs with multicentric lymphoma, CRP changes response to chemotherapy, and can be used as a marker for relapse lymphoma. Design —Cohort study. Animals —20 lymphoma 8 healthy control undergoing chemotherapy cyclophosphamide, vincristine, prednisone (CVP) or methotrexate, L-asparaginase (VCMA) 20 other dogs. Procedures —Serum was measured weekly during the first month of then at 3-week intervals until 16 weeks once not chemotherapy. Results —For both groups mean week 1 (prior treatment) significantly higher than concentrations following induction time relapse.Mean different any from chemotherapy.No significant dif ferences were observed between treated CVP VCMA. Conclusions Clinical Relevance —Results suggest that but useful itself does affect concentration.