Multidrug-resistant wound infections are associated with greater mortality, larger costs, and longer hospitalizations than susceptible infections in canine patients

• DOI: 10.2460/javma.24.11.0727
• Publication Date: 2025-02-07T18:15:24Z
• Authors: Delaina Allegretti; Scarlett M. Sumner; Laura Huber; Katelyn Hlusko; Kayla M. Corriveau; Brad Matz; Michael Tillson

To investigate the prevalence, risk factors, and economic impact of multidrug-resistant (MDR) infections in dogs at a tertiary referral hospital. This was retrospective cohort study including with positive aerobic culture associated traumatic wound or surgical site infection between July 2018 November 2023. Data collected from medical records included signalment, type, results, medications (antibiotics, NSAIDs, steroids, immunosuppressives), care, hospitalization duration, concurrent illnesses, variables, cost. Multivariable logistic regression analysis performed to identify factors MDR development. 80 met inclusion criteria, 19 had infections. Multidrug resistance increased odds longer duration by 2.98 times (95% CI, 1.09 8.19), mortality rates 11.8 1.24 112.08), total costs 3.57 1.3 9.83). Steroid use within past year, NSAID steroid 1 week before culture, initial preculture either penicillin clindamycin 3 months development 4.51 7.4 1.71 32.09). Multidrug-resistant were greater mortality, larger costs, hospitalizations. Risk for culture. pathogens have clinical impacts on veterinary healthcare, there is need implement standardized surveillance prevention programs hospitals.