Protective effects against abortion and fetal infection following exposure to bovine viral diarrhea virus and bovine herpesvirus 1 during pregnancy in beef heifers that received two doses of a multivalent modified-live virus vaccine prior to breeding

• DOI: 10.2460/javma.241.4.484
• Publication Date: 2012-08-01T14:35:30Z
• Authors: M. Daniel Givens; M. Shonda D. Marley; Craig A. Jones; Douglas T. Ensley; Patricia K. Galik; Yijing Zhang; Kay P. Riddell; Kellye S. Joiner; Bruce W. Brodersen; Soren P. Rodning
• Keywords: Bovine herpesvirus 1; Beef Cattle; Passive immunity

To determine whether administration of 2 doses a multivalent, modified-live virus vaccine prior to breeding heifers would provide protection against abortion and fetal infection following exposure pregnant cattle persistently infected (PI) with bovine viral diarrhea (BVDV) acute herpesvirus 1 (BHV1) infection.Randomized controlled clinical trial.33 crossbred beef heifers, 3 steers, 6 bulls, 25 calves.20 22 vaccinated 10 11 unvaccinated became were commingled steers PI BVDV type 1a, 1b, or for 56 days beginning 102 after the second vaccination (administered 30 first vaccination). Eighty removal BVDV-PI bulls BHV1 14 days.After exposure, fetus (not evaluated) was aborted by heifer; detected in 0 19 calves from all 4 fetuses (aborted exposure) heifers. Bovine not any calf associated membranes either treatment group. Vaccinated had longer gestation periods greater birth weights, weaning average daily gains, market value at weaning, compared those born heifers.Prebreeding resulted fewer abortions offspring improved growth increased weaned calves.