Investigation of a combination of amiodarone and itraconazole for treatment of American trypanosomiasis (Chagas disease) in dogs

• DOI: 10.2460/javma.255.3.317
• Publication Date: 2019-07-12T12:46:21Z
• Authors: Roy Madigan; Sean Majoy; Kristine Ritter; Juan Luis Concepción; María Elizabeth M...; Sasha Caribay Silva; Chih-Ling Zao; Alexandra Pérez A...; Alfonso J. Rodrig...; Adriana C. Mogoll...; J. Scot Estep; Gustavo Benaím; Alberto E. Paniz-...
• Keywords: Chagas Disease

Abstract OBJECTIVE To evaluate clinical, serologic, parasitological, and histologic outcomes of dogs with naturally occurring Trypanosoma cruzi infection treated for 12 months amiodarone itraconazole. ANIMALS 121 from southern Texas Louisiana. PROCEDURES Treatment group (n = 105) received a combination hydrochloride (approx 7.5 mg/kg [3.4 mg/lb], PO, q 24 h, or without loading dosage protocol) itraconazole 10 [4.5 adjusted to maintain plasma concentration 1 2 μg/mL) months. Control 16) no antitrypanosomal medications. Serologic assays anti- T antibodies, PCR DNA in blood, physical evaluations were performed 1, 6, 9, 12, after study initiation. Adverse events recorded. Outcomes interest recorded compared between groups. RESULTS 86 105 treatment 8 16 control survived completed the (5/19 6/7 deaths dogs, respectively, attributed infection). Mean survival time until death was longer (23.19 vs 15.64 months) group. Results negative all 92) tested (except dog at point) 6 Clinical improvement ≥ clinical sign observed 53 54 0 respectively; adverse drug minor reversible. CONCLUSIONS AND CLINICAL RELEVANCE suggested efficacy this trypanocidal dogs.