Evaluation of neutrophilia as a prognostic factor in dogs with multicentric lymphoma treated with a cyclophosphamide, doxorubicin, vincristine, and prednisone–based chemotherapy protocol
Lymphoma
04 agricultural and veterinary sciences
Prognosis
3. Good health
0403 veterinary science
Dogs
Doxorubicin
Vincristine
Antineoplastic Combined Chemotherapy Protocols
Tumor Microenvironment
Animals
Prednisone
Dog Diseases
Prospective Studies
Cyclophosphamide
Retrospective Studies
DOI:
10.2460/javma.259.5.494
Publication Date:
2021-08-13T18:05:03Z
AUTHORS (3)
ABSTRACT
Abstract
OBJECTIVE
To determine whether, in dogs with naïve multicentric lymphoma, neutrophilia at the time of initial diagnosis was associated with progression-free survival time (PFST) or overall response rate (ie, percentage of dogs with a complete or partial remission) and whether the initial neutrophil-to-lymphocyte ratio was associated with PFST.
ANIMALS
30 dogs with multicentric lymphoma and neutrophilia (including 16 treated with a cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP]–based protocol) and 37 historical control dogs without neutrophilia treated with a CHOP-based protocol.
PROCEDURES
Medical records were reviewed, and PFSTs and responses were documented.
RESULTS
Median PFST for the 16 dogs with neutrophilia treated with a CHOP-based protocol (70 days; range, 0 to 296 days) was significantly shorter than that for the 37 control dogs without neutrophilia (184.5 days; range, 23 to 503 days), and the overall response rate for dogs with neutrophilia (12/16 [75%]) was significantly lower than the rate for dogs without neutrophilia (36/37 [97%]). However, when all dogs in the study and control populations were considered together, the neutrophil-to-lymphocyte ratio at the time of diagnosis was not significantly associated with PFST.
CONCLUSIONS AND CLINICAL RELEVANCE
Results suggested that neutrophilia at the time of initial diagnosis may suggest a poorer prognosis in dogs with multicentric lymphoma. Prospective investigation into the role of neutrophils in the peripheral circulation and tumor microenvironment of cancer-bearing patients is warranted.
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CITATIONS (2)
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