Multidrug-resistant tuberculosis in Belarus: the size of the problem and associated risk factors

• DOI: 10.2471/blt.12.104588
• Publication Date: 2013-02-04T15:24:49Z
• Authors: Alena Skrahina; Henadz Hurevich; Aksana Zalutskaya; Evgeni Sahalchyk; Andrei Astrauko; Sven Hoffner; Valiantsin Rusovich; Andrei Dadu; Pierpaolo de Colo...; Masoud Dara; Wayne van Gemert; Matteo Zignol
• Keywords: Adult; Male; 0301 basic medicine; Adolescent; Republic of Belarus; Mycobacterium tuberculosis; Middle Aged; Health Surveys; Young Adult; 03 medical and health sciences; Age Distribution; Risk Factors; Tuberculosis, Multidrug-Resistant; Confidence Intervals; Odds Ratio; Humans; Female; Public aspects of medicine; RA1-1270; Sex Distribution

Objective To assess the problem of multidrug-resistant tuberculosis (MDR-TB) throughout Belarus and investigate associated risk factors.Methods In a nationwide survey in 2010-2011, 1420 (TB) patients were screened 934 new 410 previously treated cases TB found to meet inclusion criteria.Isolates Mycobacterium from each eligible patient tested for susceptibility anti-TB drugs.Sociobehavioural information was gathered interviews based on structured questionnaire.Findings MDR-TB 32.3% 75.6% patients, respectively, and, 11.9% 612 have had extensively drug-resistant (XDR-TB).A history previous treatment strongest independent factor (odds ratio, OR: 6.1; 95% confidence interval, CI: 4.8-7.7).The other factors human immunodeficiency virus (HIV) infection (OR: 2.2; 1.4-3.5),age < 35 years 1.4; 1.0-1.8),history imprisonment 1.5; 1.1-2.0),disability sufficient prevent work 1.9; 1.2-3.0),alcohol abuse 1.3; 1.0-1.8)and smoking 1.1-2.0).Conclusion is very common among Belarus.The numerous identified convergence epidemics HIV call not only stronger collaboration between control programmes, but also implementation innovative measures accelerate detection resistance improve adherence.