Hydraulic expansion facilitates remodeling of arteriovenous fistulas without increasing venous intimal hyperplasia in rabbits

• DOI: 10.2478/abm-2021-0028
• Publication Date: 2021-11-09T18:24:33Z
• Authors: Wanjun Ren; Jiyuan Niu; Yuejuan Du; Huili Jiang
• Keywords: Intimal hyperplasia; Elastic fiber; Neointima

Abstract Background An arteriovenous fistula (AVF) is considered essential for chronic hemodialysis. Objective To determine the effects of hydraulic expansion on intimal hyperplasia an AVF. Methods We divided 12 healthy male New Zealand white rabbits into a control group (vein without special handling and direct anastomosis with artery, n = 6) dilated by pressure before anastomosis, 6). Histopathomorphology was examined hematoxylin eosin staining immunohistochemistry. Analysis covariance (ANCOVA) used to compare data between groups. Results Immediately 1 day after surgery, diameter vein in significantly larger than it ( P 0.02 0.03 respectively), but not subsequent days. After construction fistula, wall noticeably thinner macroscopic observation, anterior posterior walls were indistinguishable. At 3 weeks surgery group, cells disordered, there fewer elastic fibers, tissues from endothelium tunica externa less dense, extracellular matrix group. Expression connective tissue growth factor that 0.01). No differences found thickness or immunohistochemistry scores transforming factor-β1 Conclusion Hydraulic did increase AVF, facilitates remodeling AVFs rabbits.