Interstitial Cajal-Like Cells and Bile Lithogenicity in the Pathogenesis of Gall-Stone Disease

• DOI: 10.2478/pjs-2013-0046
• Publication Date: 2013-07-04T12:52:39Z
• Authors: Artur Pasternak; Andrzej Matyja; Krzysztof Gil; Mariusz Gajda; Krzysztof A. Toma...; Maciej Matyja; Jerzy A. Walocha; Jan Kulig
• Keywords: Pathogenesis

Gall-stone disease constitutes a serious clinical problem and is the most frequent cause of elective cholecystectomies. There are many etiopatogenic factors however; lithogenic bile its stasis due to gall-bladder hypomotility seem be important. In recent years discovery pacemaker function Interstitial Cells Cajal changed our understanding smooth muscle physiology helped disclose gastrointestinal motility disorders.was identification quantification interstitial Cajal-like cells (ICLCs) in wall from patients with cholelithiasis gall-stone-free controls, as well determination relationship between number ICLCs Cholesterol Saturation Index (CSI) both analyzed groups.20 operated for symptomatic were enrolled into study group. The control group consisted 20 pancreatic head tumors, no pre- intraoperative signs gall-stones. Identification was performed by means double immunofluorescence technique anti c-Kit anti-mast cell tryptase antibodies. Quantitative analysis carried out under fluorescence microscopy conjoined image software. Bile samples used calculation CSI.ICLCs detected within wall. Number statistically significantly lower compared control. also revealed higher CSI group.The quantity diminished there negative correlation bile. Regarding role ICCs regulation GI tract motility, it appears that reduction their may important factor cholelithiasis.