Contemporary Distribution of High-Grade Prostate Cancer in the Circumstances of Opportunistic Testing

• DOI: 10.2478/sjecr-2018-0030
• Publication Date: 2019-01-10T09:03:10Z
• Authors: Milorad M Stojadi...; Damjan N Pantic; Miroslav M Stojad...
• Keywords: Rectal examination; Univariate analysis; Prostate biopsy

Abstract Screening has dramatically changed the distribution of mean age, stage and grade prostate cancer (PCa) at diagnosis. However, regional-level data that characterize contemporary PCa patients are limited. The aim study was to ascertain main clinical pathological characteristics present time in circumstances opportunistic testing. High-grade according serum specific antigen (PSA), volume prostate, PSA density (PSAD), digital rectal examination (DRE) number positive cores biopsies average percentage biopsy diagnosis been retrospectively evaluated 100 men with biopsyproven PCa, Clinical Centre Kragujevac, from September 2016 until 2017. were stratified Gleason score (GS) into low/intermediate-grade (GS ≤ 7) high-grade ≥ 8). To identify determinants associated we performed univariate multivariate logistic regression. most prevalent (65%), followed by (35%). age 71.5 (range: 56–88) years median 14.6 1.4–935) ng/ml. There significant differences PSA, PSAD, DRE, between or without GS. Logistic analysis demonstrated PSAD have strong prognostic value PCa. In conclusion, our shown worrying frequency Older higher level had a much probability