Anticholinergic and Sedative Drug Burden and Functional Recovery after Cerebrovascular Accident: A Retrospective Descriptive Study

• DOI: 10.2490/prm.20200010
• Publication Date: 2020-05-15T22:05:32Z
• Authors: Yukari Ogawa; Futoshi Nibe; Ryuichi Ogawa; Masaharu Sakoh
• Keywords: Functional Independence Measure; Berg Balance Scale; Stroke

Medications with anticholinergic or sedative effects induce impaired cognitive and physical performances. The aim of this study was to evaluate the associations drug burden recovery function activities daily living in patients admitted a Japanese rehabilitation hospital after cerebrovascular accidents.We retrospectively reviewed medical records aged 18 years older who had undergone inpatient program for disease Nerima Ken-ikukai Hospital. Patients did not complete because acute unexpected changes psychological condition need surgical procedures were excluded. primary outcome as measured by motor subscores Functional Independence Measure. secondary assessed 10-m walk test Berg balance scale. Multiple Cox proportional hazard regression analyses conducted calculate ratios 95% confidence intervals measures.Of 122 included study, 81 (66%) exposed anticholinergics sedatives. Patients' age, body mass index, average during hospitalization independently associated achieving cutoff Measure-motor subscore. age scale cut-off score.Our transferred from stroke care hospitals facility identified sedatives an independent factor time postural balance.