Mechanisms of Age Differences in the Effectiveness of Phototherapy of Glioblastoma

• DOI: 10.24976/discov.med.202537193.27
• Publication Date: 2025-02-20T03:25:33Z
• Authors: Alexander Shirokov; Nikita Navolokin; Alla Bucharskaya; Inna Blokhina; Andrey Terskov; Maria Tzoy; Alexander Dubrovsky; Ivan Fedosov; Oxana Semyachkina...

Glioblastoma is an incurable and aggressive oncological disease of the brain. Recent studies have shown that transcranial non-invasive photobiomodulation a promising new alternative method for suppression glioblastoma growth. The lymphatic endothelium meningeal vessels important target therapeutic effects photobiomodulation. However, functions decline with age. Therefore, it remains unknown whether can be effective in adults elderly. To answer this question, study examined role brain drainage age-related differences resistance to glioblastoma. were performed on 6- 24-month-old rats using model fluorescent Tumor progression was assessed magnetic resonance imaging Fluor I vivo fluorescence system. Photobiomodulation 14 days phototherapy or once photoeffects brain's drainage. Brain studied by optical excretion dye from deep cervical lymph nodes, as well assessing water content tissues intracranial pressure. Histological immunohistochemical methods used apoptosis, proliferation migration CD8+ cells peripheral system We clearly show network reduced vs. 6-month-old animals (p < 0.001), which accompanied decrease development significantly increases survival but not via improvement vessels, including facilitating traffic protective reducing pressure edema. blockade communication between systems completely suppresses 0.001). Thus, stimulation immunity increasing early late ontogenesis due vessels.