Sleep quality in patients with chronic spontaneous urticaria and relation with Orexin-A, leptin, and ghrelin

• DOI: 10.2500/aap.2024.45.240023
• Publication Date: 2024-07-10T04:33:48Z
• Authors: Selcan Gultuna; Buket Basa Akdogan; Muzeyyen Gonul; Fevzi Nuri Aydin; Simge Unal; Gokce Nebioglu Erkek; Funda Seher Ozalp...; Melike Bagnu Yuceege; Sinem Ayse Ornek ...
• Keywords: Leptin; Male; Adult; Orexins; Middle Aged; Ghrelin; Young Adult; 03 medical and health sciences; Sleep Quality; 0302 clinical medicine; Case-Control Studies; Surveys and Questionnaires; Quality of Life; Humans; Female; Chronic Urticaria

Background: Sleep can be affected in patients with chronic spontaneous urticaria (CSU). The mechanisms of sleep regulation remain poorly understood. Orexin-A, a neuroexcitatory peptide, plays a role in coordinating sleep-wake states. Ghrelin and leptin are involved in sleep regulation through the orexin system. Objective: The effects of orexin-A, ghrelin, and leptin on sleep quality in patients with CSU have not been investigated. We aimed to determine the effects of CSU on sleep quality and the association between serum orexin-A, ghrelin, and leptin levels, and sleep quality in patients with CSU. Methods: Thirty-three patients with CSU and 34 sex- and age-matched controls were included in the study. Serum orexin-A, leptin, and ghrelin levels, and the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) scores were measured in patients with CSU and in the controls; also used were the chronic urticaria quality-of-life questionnaire score and the urticaria activity score used for 7 consecutive days. Results: Median (minimum-maximum) orexin-A, leptin, and ghrelin levels in patients were 385 pg/mL (90‐495 pg/mL), 3.1 ng/mL (0‐21.2 ng/mL), and 701.8 pg/mL (101.9‐827.7 pg/mL), respectively. Median serum orexin-A and leptin levels were higher in the patients compared with the controls (p < 0.001 and p = 0.012, respectively), whereas the median serum ghrelin levels were similar to the controls (p = 0.616). The serum orexin-A level was positively correlated with ghrelin (r = 0.298, p = 0.014), PSQI sleep quality (r = 0.356, p = 0.003), and ESS (r = 0.357, p = 0.003). Conclusion: Serum orexin-A is associated with sleep quality in patients with CSU. Further studies are needed to elucidate the role of ghrelin and leptin on sleep quality in patients with CSU.