Immunohaematological profile and ancestry informative markers in individuals with COVID-19

• DOI: 10.25248/reas.e18486.2025
• Publication Date: 2025-04-25T18:29:11Z
• Authors: Gabriel Barroso d...; Thais Ferreira Bo...; Dyjaene de Jesus ...; Alex José Leite T...; Rogério Reis Conc...; Isa Rita Brito de...; Soraya Castro Tri...; Vitor Antonio For...; Simone Simionato; Silvana Beutinger...
• Keywords: 2019-20 coronavirus outbreak

Objective: To evaluate the hematological and lymphocyte profiles of individuals with COVID-19, as well to identify ancestral profile through Ancestry Informative Markers from two cities in Northeast region Brazil. Methods: Data 58 COVID-19 who presented mild (39) severe (19) clinical conditions were analyzed. The was identified by immunophenotyping genotyping via PCR qPCR analysis. analyzed descriptive statistics using IBM SPSS Statistics software. study approved Research Ethics Committee (ICS-UFBA). Results: Individuals group showed an increase total leukocytes neutrophils, a decrease erythrocytes, hemoglobin, hematocrit, lymphocytes compared group. Likewise, cellular CD4+ T cells, CD8+ B lymphocytes. Regarding profile, both groups had greater European genomic profile. However, higher percentage African ancestry Conclusion: not associated severity, but results match findings that individuals' immune responses play crucial role COVID-19.