Cervical cancer and XRCC1 gene polymorphisms

• DOI: 10.25248/reas.e20401.2025
• Publication Date: 2025-05-30T16:36:27Z
• Authors: Andréia Michelle ...; Ivan de Alcântara...; Israel Santos da ...; Karla Roberta Lem...; Ivan Barbosa Barros; Maria de Mascena ...; Paulo Roberto Ele...
• Keywords: XRCC1

Objective: To undertake a literature review on the development of cervical cancer, emphasizing epidemiological data, human papillomavirus (HPV) infection in carcinogenesis, and role XRCC1 gene DNA repair, order to provide valuable information for medical scientific community. The goal is resource clinical practice. Bibliographic Review: Cervical cancer ranks as fourth most common malignancy worldwide. Despite known environmental, behavioral, genetic risk factors, their management remains inadequate. Persistent with oncogenic HPV well-established factor; however, not all infected individuals develop suggesting involvement additional mechanisms. Among these, polymorphisms have gained attention. encodes scaffold protein essential repair coordination cell cycle regulation. Three main polymorphisms—Arg194Trp, Arg280His, Arg399Gln—are associated impaired genomic instability, increased susceptibility. Final Considerations: A deeper understanding cellular mechanisms underlying may facilitate targeted interventions women, contributing improved quality life reduced mortality.