Hypersensitivity reactions induced by proton pump inhibitors: diagnostic and management strategies

• DOI: 10.26416/aler.7.3.2023.8790
• Publication Date: 2023-11-28T08:17:08Z
• Authors: Alexandra Tiţa; Roxana-Marcela Cr...; Ana-Maria-Andreea...; Selda Ali; Roxana Silvia Bum...
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Proton pump inhibitors (PPIs) are highly safe medicines, commonly used as first-line treatment for various digestive diseases. However, the use of PPIs expands, hypersensitivity reactions (HSRs), including both immediate and delayed reactions, have become more prevalent. The most frequent HSR observed in patients treated with is anaphylaxis. Skin tests (prick intradermal) followed by an oral challenge test suggested accurately diagnosing HSRs to PPIs, due their high specificity. It crucial understand patterns cross-reactivity among different establish a therapeutic option evaluate alternative drugs within same class. If patient does not tolerate available options no other equally effective chemically unrelated available, desensitization protocol should be initiated ensure continuous medical treatment.