A clinical case of treatment of recurrent inoperable locally advanced breast cancer using conformal radiotherapy. Case report

• DOI: 10.26442/18151434.2024.4.202874
• Publication Date: 2025-02-18T07:42:26Z
• Authors: Sergey V. Medvedev; Maria Yu. Vlasova; Larisa V. Bolotina; Andrey D. Kaprin; Evgeny V. Khmelev...; Aziz D. Zikiryakh...; Shakhnoz G. Khaki...; Gulnoz G. Khakimova; Natalya M. Bychkova; Natalia A. Zaitseva; Elnara R. Abushova; Svetlana D. Guseva; Egor D. Maslov
• Keywords: Recurrent breast cancer

Despite advances in the early diagnosis of breast cancer (BC), identification locally advanced forms continues to be relevant. This is a complex category patients whose treatment includes use various methods with significant medical and economic costs, long-term rehabilitation. A particular difficulty cases progression forms. Patients BC require multidisciplinary approach. In absence an effect after neoadjuvant drug impossibility performing surgical intervention, are treated induction radiation therapy. The article describes features therapy primary inoperable specific clinical example. case recurrence triple negative type BC, patient underwent regimens inclusion immunotherapy. Due lack from 3 lines systemic treatment, it was decided conduct connection identified carrier mutation BRCA1 gene, targeted PARP inhibitors prescribed. Two months 1 month start therapy, showed complete resorption tumor conglomerate on anterior chest wall. conformal disease made possible completely resorb exophytic ulceration achieve remission within next 6 months.