Derangements of Liver enzymes in Covid-19 positive patients of Pakistan: A retrospective comparative analysis with other populations

• DOI: 10.26502/ami.93650050
• Publication Date: 2020-07-19T12:39:00Z
• Authors: Muhammad Sohaib A...; Mohammed Akram; Uzma Rasheed; Maira Hassan; Zehra Iqbal; Basmah Fayaz; Huzaifa Hayat; Ayesha Ather; Hamzah Hussain; Erum Syyed
• Keywords: Liver function; Gamma-glutamyltransferase

Background & Objectives: COVID-19 is a global pandemic, also affecting Pakistan with its first case reported on 26th February 2020. Since then, it has been total of 217,809 positive cases and 4473 deaths in so far. Deranged liver function enzymes levels are prominently detected extra-pulmonary clinical manifestation by at least one-half the patients. Our study aimed to evaluate these derangements our population. Methods: A retrospective, observational was conducted include all admitted patients having positive, evaluated those for (n=77). The statistical analysis compare amongst disease severity, prognostic markers, death. Results: Out 77 patients, 55 were ward, 22 ICU, 61 them recovered, while 16 reported. most deranged enzyme found out be Gamma-glutamyl transferase (51.94%), followed Aspartate (41.55%), Alanine (28.57%), Alkaline phosphatase (14.28%). Total bilirubin only 10 however, direct above normal range 33 indirect component 4 Increased bilirubin, aminotransferase, associated increased mortality, ICU admissions, neutrophils, lymphocytopenia, leukocytosis, neutrophil lymphocyte ratio>3, aminotransferase not factors. Conclusion: values correlated an number mortalities as well markers.