Adult Granulosa Cell Tumor of the Ovary: Initial Evaluation and Current Treatment Paradigm

• DOI: 10.26502/jcsct.5079002
• Publication Date: 2018-07-18T09:08:48Z
• Authors: Melissa Hodeib; Ilene Tsui; Abed Sinno; Nisha Bansal; Joshua G. Cohen
• Keywords: Adjuvant Therapy; Granulosa cell

Adult granulosa cell tumor (AGCT) is a sex cord stromal (SCST) which constitutes 2-5% of all ovarian cancers. Initial treatment early stage disease includes primary surgical resection with or without adjuvant treatment. Late and recurrent management involves multimodality as the mainstay. Given rarity this its relative chemoresistance, future study needed to better guide individualize therapy for patients. Further evaluation diagnostic potential therapeutic implications involving FOXL2 mutations in AGCT warranted.