The DREAM complex represses growth in response to DNA damage in Arabidopsis

0301 basic medicine DNA Repair Arabidopsis Plant Science Genetics and Molecular Biology (miscellaneous) Biochemistry Plant Roots 03 medical and health sciences Gene Expression Regulation, Plant QK10 Plant physiology / növényélettan Toxicology and Mutagenesis Research Articles 0303 health sciences Ecology Arabidopsis Proteins QH QK Biology and Life Sciences Cell Cycle Checkpoints Plants, Genetically Modified E2F Transcription Factors Health Mutation Trans-Activators Mutant Proteins DNA Damage Signal Transduction Transcription Factors
DOI: 10.26508/lsa.202101141 Publication Date: 2021-09-28T20:35:54Z
ABSTRACT
The DNA of all organisms is constantly damaged by physiological processes and environmental conditions. Upon persistent damage, plant growth cell proliferation are reduced. Based on previous findings that RBR1, the only Arabidopsis homolog mammalian tumor suppressor gene retinoblastoma, plays a key role in damage response plants, we unravel here network RBR1 interactors under stress This led to identification homologs every DREAM component Arabidopsis, including previously not recognized LIN52. Interestingly, also discovered NAC044, mediator plants close major regulator SOG1, directly interact with LIN37B. Consistently, mutants NAC044 but double mutant two LIN37 for E2FB showed reduced sensitivities DNA-damaging Our work indicates existence multiple complexes conjunction mediate arrest after damage.
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