The DREAM complex represses growth in response to DNA damage in Arabidopsis

• DOI: 10.26508/lsa.202101141
• Publication Date: 2021-09-28T20:35:54Z
• Authors: Lucas Lang; Aladár Pettkó-Sza...; Hasibe Tunçay Elbaşı; Hirotomo Takatsuka; Yuji Nomoto; Ahmad Zaki; Stefan Dorokhov; Geert De Jaeger; Dominique Eeckhout; Masaki Ito; Zoltán Magyar; László Bögre; Maren Heese; Arp Schnittger
• Keywords: 0301 basic medicine; DNA Repair; Arabidopsis; Plant Science; Genetics and Molecular Biology (miscellaneous); Biochemistry; Plant Roots; 03 medical and health sciences; Gene Expression Regulation, Plant; QK10 Plant physiology / növényélettan; Toxicology and Mutagenesis; Research Articles; 0303 health sciences; Ecology; Arabidopsis Proteins; QH; QK; Biology and Life Sciences; Cell Cycle Checkpoints; Plants, Genetically Modified; E2F Transcription Factors; Health; Mutation; Trans-Activators; Mutant Proteins; DNA Damage; Signal Transduction; Transcription Factors

The DNA of all organisms is constantly damaged by physiological processes and environmental conditions. Upon persistent damage, plant growth cell proliferation are reduced. Based on previous findings that RBR1, the only Arabidopsis homolog mammalian tumor suppressor gene retinoblastoma, plays a key role in damage response plants, we unravel here network RBR1 interactors under stress This led to identification homologs every DREAM component Arabidopsis, including previously not recognized LIN52. Interestingly, also discovered NAC044, mediator plants close major regulator SOG1, directly interact with LIN37B. Consistently, mutants NAC044 but double mutant two LIN37 for E2FB showed reduced sensitivities DNA-damaging Our work indicates existence multiple complexes conjunction mediate arrest after damage.