The DREAM complex represses growth in response to DNA damage in Arabidopsis
0301 basic medicine
DNA Repair
Arabidopsis
Plant Science
Genetics and Molecular Biology (miscellaneous)
Biochemistry
Plant Roots
03 medical and health sciences
Gene Expression Regulation, Plant
QK10 Plant physiology / növényélettan
Toxicology and Mutagenesis
Research Articles
0303 health sciences
Ecology
Arabidopsis Proteins
QH
QK
Biology and Life Sciences
Cell Cycle Checkpoints
Plants, Genetically Modified
E2F Transcription Factors
Health
Mutation
Trans-Activators
Mutant Proteins
DNA Damage
Signal Transduction
Transcription Factors
DOI:
10.26508/lsa.202101141
Publication Date:
2021-09-28T20:35:54Z
AUTHORS (14)
ABSTRACT
The DNA of all organisms is constantly damaged by physiological processes and environmental conditions. Upon persistent damage, plant growth cell proliferation are reduced. Based on previous findings that RBR1, the only Arabidopsis homolog mammalian tumor suppressor gene retinoblastoma, plays a key role in damage response plants, we unravel here network RBR1 interactors under stress This led to identification homologs every DREAM component Arabidopsis, including previously not recognized LIN52. Interestingly, also discovered NAC044, mediator plants close major regulator SOG1, directly interact with LIN37B. Consistently, mutants NAC044 but double mutant two LIN37 for E2FB showed reduced sensitivities DNA-damaging Our work indicates existence multiple complexes conjunction mediate arrest after damage.
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