Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis
Short-chain fatty acid
Peritoneal fluid
DOI:
10.26508/lsa.202101224
Publication Date:
2021-09-30T17:14:03Z
AUTHORS (9)
ABSTRACT
Worldwide, ∼196 million are afflicted with endometriosis, a painful disease in which endometrial tissue implants and proliferates on abdominal peritoneal surfaces. Theories the origin of endometriosis remained inconclusive. Whereas up to 90% women experience retrograde menstruation, only 10% develop suggesting that factors alter environment might contribute endometriosis. Herein, we report whereas some gut bacteria promote others protect against by fermenting fiber produce short-chain fatty acids. Specifically, found altered microbiota drives endometriotic lesion growth feces from mice contained less acid n-butyrate than without Treatment reduced both mouse lesions human pre-clinical model. Mechanistic studies revealed inhibited cell survival through G-protein–coupled receptors, histone deacetylases, GTPase activating protein, RAP1GAP. Our findings will enable future aimed at developing diagnostic tests, metabolites treatment strategies, dietary supplements, analogs, or probiotics for
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