Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis

• DOI: 10.26508/lsa.202101224
• Publication Date: 2021-09-30T17:14:03Z
• Authors: Sangappa B Chadchan; Pooja Popli; Chandrasekhar R A...; Eric Tycksen; Sang Jun Han; Serdar E Bulun; Nagireddy Putluri; Scott W Biest; Ramakrishna Komma...
• Keywords: Short-chain fatty acid; Peritoneal fluid

Worldwide, ∼196 million are afflicted with endometriosis, a painful disease in which endometrial tissue implants and proliferates on abdominal peritoneal surfaces. Theories the origin of endometriosis remained inconclusive. Whereas up to 90% women experience retrograde menstruation, only 10% develop suggesting that factors alter environment might contribute endometriosis. Herein, we report whereas some gut bacteria promote others protect against by fermenting fiber produce short-chain fatty acids. Specifically, found altered microbiota drives endometriotic lesion growth feces from mice contained less acid n-butyrate than without Treatment reduced both mouse lesions human pre-clinical model. Mechanistic studies revealed inhibited cell survival through G-protein–coupled receptors, histone deacetylases, GTPase activating protein, RAP1GAP. Our findings will enable future aimed at developing diagnostic tests, metabolites treatment strategies, dietary supplements, analogs, or probiotics for