Basonuclin-2 regulates extracellular matrix production and degradation

• DOI: 10.26508/lsa.202301984
• Publication Date: 2023-08-09T15:52:38Z
• Authors: Ayla Orang; B Kate Dredge; Chi Yau Liu; Julie M Bracken; Chun-Hsien Chen; Laura Sourdin; Holly J Whitfield; Rachael Lumb; Sarah T Boyle; Melissa J Davis; Michael S Samuel; Philip A Gregory; Yeesim Khew-Goodall; Gregory J Goodall; Katherine A Pillman; Cameron P Bracken
• Keywords: Epithelial-Mesenchymal Transition; basonuclin-2; 3. Good health; Extracellular Matrix; DNA-Binding Proteins; extracellular matrix production; Neoplasms; cell biology; Tumor Microenvironment; cancer; Humans; Collagen; Research Articles; Genome-Wide Association Study

Epithelial-mesenchymal transition is essential for tissue patterning and organization. It involves both regulation of cell motility alterations in the composition organization ECM-a complex environment proteoglycans fibrous proteins homeostasis, signaling response to chemical biomechanical stimuli, often dysregulated under conditions such as cancer, fibrosis, chronic wounds. Here, we demonstrate that basonuclin-2 (BNC2), a mesenchymal-expressed gene, is, strongly associated with cancer developmental defects across genome-wide association studies, novel regulator ECM degradation. We find at endogenous levels, BNC2 controls expression specific collagens, matrix metalloproteases, other matrisomal components breast cells, fibroblasts are primarily responsible production processing within tumour microenvironment. In so doing, modulates motile invasive properties cancers, which likely explains high increasing grade poor patient prognosis.