Stability of gut microbiome after COVID-19 vaccination in healthy and immuno-compromised individuals

• DOI: 10.26508/lsa.202302529
• Publication Date: 2024-02-05T19:00:10Z
• Authors: Rebecca H Boston; Rui Guan; Lajos Kalmar; Sina Beier; Emily C Horner; Nonantzin Berista...; Juan Carlos Yam-Puc; Pehuén Pereyra Ge...; Luisa Faria; Anna Kuroshchenkova; Anna E Lindell; Sonja Blasche; Andrea Correa-Nog...; Anne Elmer; Caroline Saunders; Areti Bermperi; Sherly Jose; Nathalie Kingston; ; Sofia Grigoriadou; Emily Staples; Matthew S Buckland; Sara Lear; Nicholas J Matheson; Vladimir Benes; Christine Parkinson; James ED Thaventh...; Kiran R Patil
• Keywords: Dysbiosis

Bidirectional interactions between the immune system and gut microbiota are key contributors to various physiological functions. Immune-associated diseases such as cancer autoimmunity, efficacy of immunomodulatory therapies, have been linked microbiome variation. Although COVID-19 infection has shown cause microbial dysbiosis, it remains understudied whether inflammatory response associated with vaccination also impacts microbiota. Here, we investigate temporal impact on in healthy immuno-compromised individuals; latter included patients primary immunodeficiency immunomodulating therapies. We find that remained remarkably stable post-vaccination irrespective diverse status, vaccine response, composition spanned by cohort. The stability is evident at all evaluated levels including diversity, phylum, species, functional capacity. Our results indicate resilience host changes triggered suggest minimal, if any, microbiome-mediated processes. These findings encourage acceptance, particularly when contrasted significant shifts observed during infection.