PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferation

• DOI: 10.26508/lsa.202402755
• Publication Date: 2024-08-07T14:55:21Z
• Authors: Peng Wang; Zixian Li; Sung-Hoon Kim; Haijin Xu; Hao Huang; Chutong Yang; Abby Snape; Jung-Hyun Choi; Sara Bermudez; Marie-Noelle Boivin; Nicolas Ferry; Jason Karamchandani; Bhushan Nagar; Nahum Sonenberg
• Keywords: EIF4E; Eukaryotic translation; EIF4A1; Initiation factor; Eukaryotic initiation factor

The mRNA 5'cap-binding eukaryotic translation initiation factor 4E (eIF4E) plays a critical role in the control of health and disease. One mechanism regulation eIF4E activity is via phosphorylation by MNK kinases, which promotes subset mRNAs encoding pro-tumorigenic proteins. Work on phosphatases has been paltry. Here, we show that PPM1G phosphatase dephosphorylates eIF4E. We describe eIF4E-binding motif similar to 4E-binding proteins (4E-BPs). demonstrate inhibits cell proliferation targeting phospho-eIF4E-dependent translation.