Optimization of Nanoemulsion Formula Containing Erythromycin with VCO and Varying Concentrations of Tween-80 and PEG-400

• DOI: 10.26554/sti.2024.9.3.697-709
• Publication Date: 2024-07-03T05:05:26Z
• Authors: Mardiyanto; Risfidian Mohadi; Najma Annuria Fithri; Gilang Kurniawan
• Keywords: PEG 400

Erythromycin, a macrolide antibiotic is classified into Biopharmaceutical Classification System (BCS) class II which has low solubility in water. The corresponds to the bioavailability blood. One strategy increase of Erythromycin formulation erythromycin nanoemulsion. This research aims form nanoemulsion using PIT (Phase Transition Temperature) method for obtaining optimum formula virgin coconut oil (VCO) can be found with varying concentrations Tween 80 surfactant and PEG 400 cosurfactant. selection was assisted by Design Expert software Factorial design 22. basis determining based on results organoleptic characterization tests, adsorption efficiency (%EE), percent transmittance, viscosity test, pH stability test. had concentration 25% as desirability value <1. showed that particle size 170.6±12.8594 nm, polydispersity index (PDI) 0.403±0.04406, zeta potential -8.8667±0.25697 mV an appropriate without phase separation during