genome-wide association study for different types allergic diseases

• DOI: 10.26577/ijbch.2022.v15.i2.04
• Publication Date: 2023-01-31T05:46:28Z
• Authors: N.K. Altynova; O.K. Khamdiyeva; Zh.A. Zhaniyazov; A.A. Garshin; G.S. Baratzhanova; A.S. Amirgalieva; K. Yergali; D.N. Artygaliyeva; D.Zh. Talgatbekova; S.S. Tokmurzina; M.S. Abdullayeva; G.S. Zhunussova; L.B. Djansugurova
• Keywords: Candidate gene; Genome-wide Association Study; SNP; Genetic Association; Genetic predisposition

All over the world, there is an active search for genes that are responsible formation of predisposition to allergic diseases, which associated both with undoubted relevance studying risk factors development allergies, and emergence new opportunities genetic research. In addition, anthropogenic impact can cause reactions modifications in functions antioxidant defense cells immune system. Due fact cohort population Almaty region (going forward we will say include also), respiratory diseases component, such as bronchial asthma, bronchitis, rhinitis, common, consider it appropriate conduct epidemiological study candidate – cytokines their receptors (IL4, IL4RA , IL12B, IL13, TNFA, CCL5), adrenoreceptor (ADRB2), transcription involved T-lymphocyte differentiation (STAT6, GATA3, TBX21), major histocompatibility complex (HLA-DRB1, HLA-DQB1). The aim our genome-wide genotyping people marker affect developing allergies well identify pathogenesis diseases. We performed microarray 25355 SNPs on iScan platform 103 samples 108 control DNA using kit (Infinium® ImmunoArray-24 v2.0 BeadChip Kit). results obtained, GWAS analysis, takes into account numerous polymorphisms, showed involvement some (rs20541-asthma, rs841718-atopic dermatitis, rs3212227-immunodeficiency).