The impact of the novel starch-lipid complexes on the glucolipids metabolism, inflammation, and gut dysbiosis of type 2 diabetes mellitus rats

• DOI: 10.26599/fshw.2023.9250008
• Publication Date: 2024-02-26T08:22:06Z
• Authors: Yingshuang Lu; Renbing Qin; Jin Wang; Fengjuan Xiang; Yan Zhang; Bowei Zhang; Dancai Fan; Huan Lü; Xuemeng Ji; Shujun Wang; Shuo Wang
• Keywords: Dysbiosis

It has been widely accepted that resistant starch (RS) provides numerous health benefits for human<strong>. </strong>In this research, we aimed at evaluating the performance of novel starch-lipid complexes, RS5, in comparison with RS2 on physical features, glucolipids metabolism, inflammation, and gut microbiota profiles Type 2 diabetes mellitus (T2DM) rats. The T2DM model was established by streptozotocin injection to high-fat-sugar fed According a serial biochemical analyses, found RS5 diets were strongly correlated enhanced homeostatic assessment insulin secretion (HOMA-IS), high-density lipoprotein cholesterol (HDL-C), adiponectin (ADP), action index (IAI), glucagon-like peptide-1 (GLP1), short-chain fatty acids (SCFAs) rats whilst negatively associated low-density (LDL-C) inflammatory cytokines, showing capabilities ameliorate symptoms regulation glucolipid metabolites, inflammation. On other hand, RS2-enriched supplementations influential mediation improve glucose metabolism. increasing evidence collected herein suggested intestinal could mediate metabolism alleviate inflammation after certain microflora nourished RS. In addition, RS intake made an impact PI3K/AKT signaling pathway might contribute improvement resistance, responses.