Vagus nerve stimulation for pediatric patients with drug-resistant epilepsy caused by genetic mutations: Two cases

• DOI: 10.26599/jnr.2020.9040014
• Publication Date: 2020-10-19T10:08:48Z
• Authors: Xiaoya Qin; Sufang Lin; Yuan Yuan; Jialun Wen; Qian Chen; Xingguo Lu; Yang Sun; Fangping Wang; Xiaoqin Tian; Ning Jiang; Jianxiang Liao; Luming Li
• Keywords: Vagus Nerve Stimulation; Drug Resistant Epilepsy; Neuromodulation

Vagus nerve stimulation (VNS) is a neuromodulation therapy increasingly used for treating drug-resistant epilepsy. However, it remains to be determined which patients are best suited the treatment, and difficult predict therapeutic effect before implantation. Mutations in some genes could lead Here we report two cases of pediatric with epilepsy treated by VNS therapy: Patient 1 <italic>ARX</italic> mutation achieved good outcomes; 2 <italic>CDKL5</italic> did not show improvement. Additionally, impact on brain networks was investigated, hoping provide empirical evidence better understanding mechanism treatment.