Electrochemically Driven Nickel-Catalyzed Phenol Synthesis via Sustainable Oxygen Atom Transfer from Nitrous Oxide

• DOI: 10.26689/jera.v9i2.9879
• Publication Date: 2025-04-24T01:20:51Z
• Authors: Qiyu Zhang; Wenbin Xie; Yasser M. A. Mohamed; Hossam A. El Nazer; Ahmed A. Elnazer; Yinghui Han
• Keywords: Nitrous oxide; Nickel oxide

The valorization of nitrous oxide (N2O) as an oxygen atom donor presents attractive opportunity for green chemistry applications, leveraging both its industrial abundance and thermodynamically favorable oxidation potential. However, practical implementation has been constrained by the inherent kinetic inertness poor coordinating ability N2O. While prior studies achieved N2O-mediated conversion aryl halides to phenols, such transformations necessitated stoichiometric chemical reductants elevated pressure (2 atm), posing challenges in operational safety process scalability. This study focuses on electrochemical strategy that enables efficient transfer under ambient through controlled current application. methodology facilitates selective transformation iodides phenols without external reducing agents, establishing environmentally benign synthetic pathway. By replacing traditional with electrons sole equivalent, our approach addresses critical sustainability aromatic oxygenation while maintaining simplicity mild conditions.