Fucoidan serves a neuroprotective effect in an Alzheimer rsquo s disease model

• DOI: 10.2741/e855
• Publication Date: 2019-10-05T01:15:47Z
• Authors: Savarimuthu Ignac...
• Keywords: Fucoidan

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that causes memory and cognitive deficits. The present study was carried out to evaluate the protective effects of fucoidan in monocrotophos induced AD Drosophila melanogaster. In silico studies showed exhibited binding energy -9.3 kcal with proteins. Consistent this, fucoidan, dose time-dependent fashion, had inhibitory activity against cholinergic monoamine-metabolized enzymes vitro. Fucoidan inhibited increase total mRNA protein fed flies prevented changes biochemicals, neurochemicals latency time locomotor, learning by monocrotophos. Together, findings show serves neuroprotective effect model D.