Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer rsquo s disease

• DOI: 10.2741/s514
• Publication Date: 2017-09-22T20:27:58Z
• Authors: Arokiasamy Justin...
• Keywords: Male; Amyloid; Amyloid beta-Peptides; Apoptosis; Rats; 3. Good health; Amyloid beta-Protein Precursor; Disease Models, Animal; Oxidative Stress; Random Allocation; 03 medical and health sciences; Neuroprotective Agents; 0302 clinical medicine; Chlorides; Alzheimer Disease; Aluminum Chloride; Animals; Amyloid Precursor Protein Secretases; Rats, Wistar; Aluminum Compounds; Pentacyclic Triterpenes

Alzheimer's disease (AD) is the most common form of dementia, characterized by memory loss, cognitive impairment and personality disorders accompanied diffuse structural abnormalities in brain elderly people. The current investigation explored neuroprotective potential asiatic acid (AA), a natural triterpene Centella asiatica on aluminium chloride (AlCl3) induced rat model AD. Oral administration AlCl3 (100 mg/kg b.w.) for 42 days significantly elevated levels Al, activity acetyl cholinesterase expressions amyloid precursor protein, beta1-42, beta gamma secretases, glial fibrillary acidic ionized calcium binding adaptor molecule 1, interleukins -1β, 6, 4, 2, tumor necrosis factor alpha, inducible nitric oxide synthase, nuclear factor- k cyclooxygenase-2 hippocampus cortex compared to control group. Our observations suggested that AA treatment mitigated AD associated pathologies, which might be due its multiple pharmacological actions. Further studies are necessary order explore link between AlCl3-mediated oxidative stress apoptosis establish role