Association of vitamin D receptor gene variants with polycystic ovary syndrome: A case control study

• DOI: 10.29252/ijrm.13.12.793
• Publication Date: 2018-02-28T14:47:51Z
• Authors: Touraj Mahmoudi; ; Keivan Majidzadeh; ; Hamid Farahani; ; Mojgan Mirakhorli; ; Reza Dabiri; ; Hossein Nobakht; ; Asadollah Asadi
• Keywords: TaqI; FokI

Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), therefore vitamin receptor (VDR), parathyroid hormone (PTH), (INSR) gene variants might be involved the pathogenesis of PCOS.The present study was designed investigate possible associations between polymorphisms VDR, PTH, INSR genes risk PCOS.VDR, were genotyped 35 women with PCOS controls using Polymerase chain reaction - Restriction fragment length polymorphism method. Furthermore, serum levels glucose measured all participants.No significant differences observed for VDR FokI, Tru9I, TaqI, PTH DraII, NsiI, PmlI controls. However, after adjustment confounding factors, BsmI "Bb" genotype ApaI "Aa" significantly under transmitted patients (p= 0.016; OR= 0.250; 95% CI= 0.081-0.769, p= 0.017; 0.260; 0.086-0.788, respectively). PCOS, lower participants NsiI "NN" compared those "Nn + nn" genotypes (P= 0.045).The results showed association risk. These data also indicated that a marker decreased PCOS. Our findings, however, do not lend support hypothesis DraII variant plays