Association between seminal plasma neopterin and oxidative stress in male infertility: A case-control study

• DOI: 10.29252/ijrm.16.2.93
• Publication Date: 2018-04-23T14:55:13Z
• Authors: Tayebeh Ghiasvand; ; Mohammad Taghi Go...; ; Gholamreza Shafiee; ; Alireza Zamani; ; Jamshid Karimi; ; Marzieh Ghorbani; ; Iraj Amiri
• Keywords: Neopterin; Malondialdehyde

Neopterin is a significant and sensitive marker in estimating the activity of cellular immune system. Oxidative stress plays role etiology male infertility. Increased reactive oxygen species accompanied with increase neopterin level. Hence may be involved infertility.The objective this case-control study was to determine level idiopathic infertile normospermic men; furthermore, identify its relationship oxidative markers including total oxidant, malondialdehyde, sperm DNA fragmentation, antioxidant capacity seminal plasma.Forty seven forty three males were selected according WHO criteria. Their semen blood samples taken; subsequently, levels neopterin, antioxidant, fragmentation measured.The malondialdehyde plasma significantly higher than those group (p=0.038, 0.018, 0.028, respectively). Furthermore, men that control (p<0.001). Moreover, lower subjects (p=0.002). No difference observed serum between groups.The inverse correlation supports possible can suggested as monitoring diagnosis