Ionizing radiation induces ferroptosis in splenic lymphocytes of mice

• DOI: 10.29252/ijrr.19.1.99
• Publication Date: 2021-01-19T10:20:41Z
• Authors: X. Zhang; ; H. Liu; ; X. Xing; ; M. Tian; ; X. Hu; ; F. Liu; ; J. Feng; ; S. Chang; ; P. Liu; ; H. Zhang
• Keywords: 0301 basic medicine; 03 medical and health sciences

Backgrounds: It remains unclear whether radiation-induced haemorrhage in the spleen causes iron accumulation, and subsequently, ferroptosis splenic lymphocytes. In this study, we investigated occurrence of lymphocytes gamma-irradiated mice. Materials Methods: Mice were subjected to gamma radiation from a 137Cs source. Iron, Ferroportin 1, regulatory protein (IRP) levels spleen, serum hepcidin blood measured study change metabolism irradiated spleen. After Ferrostatin 1/LDN193189 was intraperitoneally injected into mice post-irradiation, viability index evaluated investigate mechanism damage induction The survival rate identify mitigator based on inhibition ferroptosis. Results: Iron accumulation (up 0.62 g/g) observed due haemorrhage-based haemosiderin. triggered IRP-ferroportin 1 axis increase level 121.65 mmol/l. LDN193189 used demonstrate that decreased mice, which subsequently demonstrated attribute with use through detection ferroptosis-related parameters. improved upon Ferrostatin-1 (60% duration 120 days) or (40% for same duration) treatment. Conclusion: Radiation-induced lymphocytes, anti-ferroptosis is potential strategy alleviate immune hematopoietic acute sickness.