CT Hounsfield Units of Brown Adipose Tissue Increase with Activation: Preclinical and Clinical Studies

• DOI: 10.2967/jnumed.109.068775
• Publication Date: 2010-02-01T19:39:56Z
• Authors: Shingo Baba; Heather A. Jacene; James M. Engles; Hiroshi Honda; Richard L. Wahl
• Keywords: Hounsfield scale; Histology; Standardized uptake value

Brown adipose tissue (BAT) densities assessed as CT Hounsfield units (HUs) were evaluated in a rodent model and patients to determine whether HUs changed relation BAT activity.Serial (18)F-FDG PET/CT was performed on rats under both room temperature control conditions after 4 h of cold-stimulation, which is known activate BAT. The maximum standardized uptake values measured, tissues examined the laboratory. Image records from cancer who underwent reviewed, 23 identified displayed high low into serial scans. compared these scans.The mean (+/-SD) cold-activated (-12.4 +/- 22.4) significantly higher than those (-27.9 9.6) controls rat model. (-71.6 18.0) with (-104.4 16.8) . A decrease relative lipid content seen activated histology.The increased animals patients, likely because consumption by