Glucose Metabolism in the Insula and Cingulate Is Affected by Systemic Inflammation in Humans

• DOI: 10.2967/jnumed.111.097014
• Publication Date: 2012-03-14T03:22:46Z
• Authors: Jonas Hannestad; Kalyani Subramanyam; Nicole DellaGioia; Beata Planeta-Wilson; David Weinzimmer; Brian Pittman; Richard E. Carson
• Keywords: Adult; Cerebral Cortex; Inflammation; Male; Behavior; Depression; Endocrine System; Amygdala; Gyrus Cinguli; 3. Good health; Endotoxins; 03 medical and health sciences; Glucose; 0302 clinical medicine; Fluorodeoxyglucose F18; Positron-Emission Tomography; Humans; Female

Depression is associated with systemic inflammation, and the inflammation caused by endotoxin administration elicits mild depressive symptoms such as fatigue reduced interest. The neural correlates of that result from are poorly defined. aim this study was to use ¹⁸F-FDG PET identify brain regions involved in response humans. <b>Methods:</b> Nine healthy subjects received double-blind (0.8 ng/kg) placebo on different days. used measure differences cerebral metabolic rate glucose following interest: insula, cingulate, amygdala. Serum levels tumor necrosis factor-α interleukin-6 were gauge inflammatory response, measured Montgomery-Åsberg Rating Scale other scales. <b>Results:</b> Endotoxin an increase Scale, increased fatigue, social interest, cytokines, higher normalized metabolism (NGM) and, at a trend level, lower NGM cingulate. Secondary analyses insula cingulate subregions indicated these changes driven right anterior There negative correlation between peak cytokine change interest NGM. positive <b>Conclusion:</b> Systemic humans causes concurrent cingulate—brain interoception, emotionality, motivation.