Localization of Hidden Insulinomas with 68Ga-DOTA-Exendin-4 PET/CT: A Pilot Study

• DOI: 10.2967/jnumed.115.157768
• Publication Date: 2015-05-22T02:06:11Z
• Authors: Kwadwo Antwi; Melpomeni Fani; Guillaume Nicolas; Christof Rottenbu...; Tobias Heye; Jean Claude Reubi; Beat Gloor; Emanuel Christ; Damian Wild
• Keywords: DOTA; Molecular Imaging

¹¹¹In-DOTA-exendin-4 SPECT/CT has been shown to be highly efficient in the detection of insulinomas. We aimed at determining whether novel PET/CT imaging with [Nle¹⁴,Lys⁴⁰(Ahx-DOTA-⁶⁸Ga)NH₂]exendin-4 (⁶⁸Ga-DOTA-exendin-4) is feasible and sensitive detecting benign <b>Methods:</b>⁶⁸Ga-DOTA-exendin-4 were performed a randomized cross-over order on 5 patients endogenous hyperinsulinemic hypoglycemia. The gold standard for comparison was histologic diagnosis after surgery. <b>Results:</b> In 4 confirmed insulinoma, whereas one patient refused surgery despite positive ⁶⁸Ga-DOTA-exendin-4 scan. patients, previously conventional (CT or MR imaging) not able localize insulinoma. correctly identified insulinoma only 2 patients. <b>Conclusion:</b> These preliminary data suggest that use hidden insulinomas feasible.