Performance Characteristics of the Whole-Body Discovery IQ PET/CT System

• DOI: 10.2967/jnumed.116.185561
• Publication Date: 2017-03-17T00:20:13Z
• Authors: Gabriel Reynés-Ll...; Cristina Gámez-Ce...; Inmaculada Romero...; Laura Rodríguez-Bel; José L. Vercher-C...; Josep M. Martí-Cl...
• Keywords: Positron emission tomography; Phantoms, Imaging; Reproducibility of Results; Equipment Design; Signal-To-Noise Ratio; Sensitivity and Specificity; Equipment Failure Analysis; Diagnòstic per la imatge; 03 medical and health sciences; Body image; 0302 clinical medicine; Imatge corporal; Neoplasms; Positron Emission Tomography Computed Tomography; Diagnostic imaging; Humans; Tomografia per emissió de positrons; Whole Body Imaging; Tumors

The aim of this study was to assess the physical performance a new PET/CT system, Discovery IQ with 5-ring detector blocks. <b>Methods:</b> Performance measured using National Electrical Manufacturers Association NU2-2012 methodology. Image quality extended by accounting for different acquisition parameters (lesion-to-background ratios [8:1, 4:1, and 2:1] times) reconstruction algorithms (VUE-point HD [VPHD], VPHD point-spread-function modeling [VPHD-S], Q.Clear). Tomographic also assessed Jaszczak phantom. Additionally, 30 patient lesions were analyzed account differences in lesion volume SUV quantification between algorithms. <b>Results:</b> Spatial resolution ranged from 4.2 mm at 1 cm 8.5 20 cm. Sensitivity center 10 22.8 20.4 kps/kBq, respectively. noise-equivalent counting rate peak 124 kcps 9.1 kBq/cm³. scatter fraction 36.2%. accuracy correction count losses randoms 3.9%. In image test, contrast recovery VPHD, VPHD-S, Q.Clear 18%, 13%, respectively (hot contrast; 10-mm sphere diameter; ratio, 2:1), 68%, 67%, 81%, (cold 37-mm 8:1). Background variability 3.4%, 3.0%, 2.1%, (ratio, 5.5%, 4.8%, 3.7%, On reconstruction, decrease penalty term (β) increased coefficients background variability. With phantom, overall when algorithm point-spread function used, use signal-to-noise ratio. Lesions VPHD-S had an SUV_mean 6.5 ± 3 7 3, (<i>P</i> &lt; 0.01), SUV_max 11 4.8 12 4, 0.01). No significant difference mean found <b>Conclusion:</b> Among various bismuth germanium oxide–based scanners, blocks has highest performance, improved sensitivity performance. improves PET quality, higher lower