18F-FDG PET Response of Skeletal (Bone Marrow and Bone) Involvement After Induction Chemotherapy in Pediatric Hodgkin Lymphoma: Are Specific Response Criteria Required?

• DOI: 10.2967/jnumed.117.205633
• Publication Date: 2018-04-13T12:55:18Z
• Authors: Thomas W. Georgi; Regine Kluge; Lars Kurch; Lidia Chavdarova; Dirk Hasenclever; Dietrich Stoevesandt; Tanja Pelz; Judith Landman-Pa...; W. Hamish Wallace; Jonas Karlen; Ana Fernández-Tei...; Michaela Cepelova; Alexander Fosså; Walentyna Balwierz; Andishe Attarbaschi; Roland A. Ammann; Jane Pears; Andrea Hraskova; Anne Uyttebroeck; Auke Beishuizen; Karin Dieckmann; Thierry Leblanc; Stephen Daw; Julia Baumann; Dieter Körholz; Osama Sabri; Christine Mauz-Kö...
• Keywords: Skeleton (computer programming)

To determine whether the current ¹⁸F-FDG PET response criterion for skeletal involvement in Hodgkin lymphoma (HL) is suitable, we performed a systematic evaluation of different types and their on after 2 cycles chemotherapy (PET-2). A secondary objective was to observe influence initial uptake intensity (measured as qPET) metabolic tumor volume (MTV) lesions PET-2 response. <b>Methods:</b> The scans 1,068 pediatric HL patients from EuroNet-PHL-C1 trial were evaluated by central review. Three distinguished: PET-only (those detected only), bone marrow (BM) (as confirmed MRI or BM biopsy), lesions. qPET MTV calculated each lesion. All assessed residual activity. rates complete nodal compared. <b>Results:</b> Of patients, 139 (13%) showed (44 PET-only, 32 BM, 63 bone). with involvement, 101 (73%) became PET-2–negative skeleton 94 (68%) lymph nodes. highest number 42 (95%) 44 followed 22 (69%) 37 (59%) patients. Lesions that lower median (2.74) (2 cm³) than remained PET-2–positive (3.84 7 cm³, respectively). <b>Conclusion:</b> In this study rate similar involvement. Bone flare seemed be irrelevant. Overall, criterion—comparison local background—is well suited. predictive result. Higher values both parameters associated worse