Combination of 68Ga-PSMA PET/CT and Multiparametric MRI Improves the Detection of Clinically Significant Prostate Cancer: A Lesion-by-Lesion Analysis

• DOI: 10.2967/jnumed.118.221010
• Publication Date: 2018-12-14T19:18:56Z
• Authors: Mengxia Chen; Qing Zhang; Chengwei Zhang; Xiaozhi Zhao; Giancarlo Marra; Jie Gao; Xiaoyu Lv; Bing Zhang; Yao Fu; Feng Wang; Xuefeng Qiu; Hongqian Guo
• Keywords: Multiparametric MRI

Our purpose was to explore whether ⁶⁸Ga-PSMA PET/CT alone (PET/CT) or in combination with multiparametric MRI (PET/MRI) can improve the detection of clinically significant prostate cancer (PCa). <b>Methods:</b> We retrospectively enrolled 54 patients who underwent both and before radical prostatectomy. Regions interest on MR images, pathologic images were marked. A lesion defined as a region marked obtained any 3 modalities. All lesions characterized using imaging reporting data system (PI-RADS), molecular PSMA expression score, results analyzed. Diagnostic performance analyzed by receiver-operating-characteristic analysis. Specific improvement for different PI-RADS scores net reclassification index (NRI). <b>Results:</b> In total, 90 from analyzed, among which 66 represented PCa. Receiver-operating-characteristic analysis showed PET/MRI perform better than detecting PCa (change area under curve, 0.06; 95% confidence interval, 0.01–0.12; <i>P</i> &lt; 0.05). With calculated cutoff, performed significantly (NRI, 21.9%; 0.01), an sensitivity (89% vs. 76%, 0.01) at no sacrifice specificity (96% 88%, &gt; Improvement diagnosing occurred classified 66.7%; 0.01). <b>Conclusion:</b> improves lesions.