Voxelwise and Patientwise Correlation of 18F-FDOPA PET, Relative Cerebral Blood Volume, and Apparent Diffusion Coefficient in Treatment-Naïve Diffuse Gliomas with Different Molecular Subtypes

• DOI: 10.2967/jnumed.120.247411
• Publication Date: 2020-07-10T01:13:25Z
• Authors: Hiroyuki Tatekawa; Akifumi Hagiwara; Jingwen Yao; Talia C. Oughourlian; Issei Ueda; Hiroyuki Uetani; Catalina Raymond; Albert Lai; Timothy F. Cloughesy; Phioanh L. Nghiemphu; Linda M. Liau; Whitney B. Pope; Noriko Salamon; Benjamin M. Ellin...
• Keywords: Isocitrate dehydrogenase; Cerebral blood volume

Our purpose was to identify correlations between ¹⁸F-fluorodihydroxyphenylalanine (¹⁸F-FDOPA) uptake and physiologic MRI, including relative cerebral blood volume (rCBV) apparent diffusion coefficient (ADC), in gliomas with different molecular subtypes evaluate their prognostic values. <b>Methods:</b> Sixty-eight treatment-naïve glioma patients who underwent ¹⁸F-FDOPA PET MRI were retrospectively selected (36 isocitrate dehydrogenase wild-type [IDH_wt], 16 mutant 1p/19q noncodeleted [IDH_m-noncodel], codeleted [IDH_m-codel]). Fluid-attenuated inversion recovery hyperintense areas segmented used as regions of interest. For voxelwise patientwise analyses, Pearson correlation coefficients (<i>r</i>_voxelwise <i>r</i>_patientwise) the normalized SUV (nSUV), rCBV, ADC evaluated. Cox regression analysis performed investigate associations overall survival <i>r</i>_voxelwise, maximum or median nSUV, ADC. <b>Results:</b> IDH_wt IDH_m-noncodel gliomas, nSUV demonstrated significant positive rCBV = 0.25 0.31, respectively; <i>r</i>_patientwise 0.50 0.70, respectively) negative −0.19 −0.19, −0.58 −0.61, both analyses. IDH_m-codel a only 0.18). In analysis, <i>r</i>_voxelwise (hazard ratio, 28.82) 0.085) had for gliomas. <b>Conclusion:</b> showed distinctive patterns amino acid MRI. Stronger may result worse prognosis